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Is DHEA Safe?

Is DHEA Safe? DHEA is a naturally occurring pro-hormone.  It is the most abundant pro-hormone in the body.  DHEA is a base building block for hormones we produce. %0 hormones use DHEA as a precursor.  The body makes DHEA and pregnenolone from cholesterol. Why would something the body produces be harmful. No medical research studies of DHEA have shown any dangerous or harmful effects.  Low levels of DHEA are associated with greater risks of cardiovascular disease, cancer, type II diabetes, obesity and dementia.  Higher levels of DHEA are associated with lower risks of cardiovascular disease, cancer, type II diabetes, obesity and dementia. “The marked decline in serum dehydroepiandrosterone (DHEA) with age is believed to play a role in health problems associated with aging, these health issues being potentially preventable or reversible by the exogenous administration of DHEA.” (Labrie F, Belanger A, Belanger P, Berube R, Martel C, Cusan L, Gomez J, Candas B, Chaussade V, Castiel I, Deloche C., Leclaire J. “Metabolism of DHEA in postmenopausal women following percutaneous administration”. Journal of Steroid Biochemistry and Molecular Biology. Feb 2007 pp 178-88) So the majority of research studies of “DHEA” administered via oral DHEA supplements and consequently showed little benefit to "DHEA"(Sulfate) were not testing DHEA with the proper method of administration.

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February 13, 2014 @ 19:44:45Current Revision
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Is DHEA Safe? Is DHEA Safe?
As a physician, I believe Twist 25 DHEA cream is the highest quality anti-aging and wellness product available.  
Recent <b>medical research studies show DHEA must be delivered to the body as a transdermal cream rather than as a pill supplement.</b> There are 3 key reasons for this.  
  DHEA is a naturally occurring pro-hormone.  It is the most abundant pro-hormone in the body.  DHEA is a base building block for hormones we produce. %0 hormones use DHEA as a precursor.  The body makes DHEA and pregnenolone from cholesterol. Why would something the body produces be harmful.
<b> Reason 1)</b> When taken as a pill, orally ingested DHEA is destroyed by the "first-pass effect" of the liver. Basically, this means that because the molecule is too large it appears to be a foreign substance, the liver filters most of the effective DHEA out before it can do any good: and, what does end up getting into the bloodstream is DHEA-S (DHEA sulphate). No medical research studies of DHEA have shown any dangerous or harmful effects.  Low levels of DHEA are associated with greater risks of cardiovascular disease, cancer, type II diabetes, obesity and dementia.  Higher levels of DHEA are associated with lower risks of cardiovascular disease, cancer, type II diabetes, obesity and dementia.
<b> Reason 2)</b> DHEA-S is not the same as DHEA. DHEA-S is a different pro-hormone and has different benefits than DHEA. New medical research shows <b>DHEA-S is not converted by the body into DHEA</b>. However, <b>DHEA <i>is</i> converted into DHEA-S</b>, but not the other way around.  
Twist 25 cream does supplement DHEA instead rather than DHEA-S.  
  “The marked decline in serum dehydroepiandrosterone (DHEA) with age is believed to play a role in health problems associated with aging, these health issues being potentially preventable or reversible by the exogenous administration of DHEA.”
(Fabian Hammer, Sandra Subtil, Philipp Lux, Christiane Maser-Gluth, Paul M. Stewart, Bruno Allolio and Wiebke Arlt. No Evidence for Hepatic Conversion of Dehydroepiandrosterone (DHEA) Sulfate to DHEA: In Vivo and in Vitro Studies. Journal of Clinical Endochrinology and Metabolism Vol. 90, No. 6 3600-3605) (Labrie F, Belanger A, Belanger P, Berube R, Martel C, Cusan L, Gomez J, Candas B, Chaussade V, Castiel I, Deloche C., Leclaire J. “Metabolism of DHEA in postmenopausal women following percutaneous administration”. Journal of Steroid Biochemistry and Molecular Biology. Feb 2007 pp 178-88)
So the majority of research studies of “DHEA” administered via <span style="text-decoration: underline;">oral</span> DHEA supplements and consequently showed little benefit to "DHEA"(Sulfate) were not testing DHEA with the proper method of administration. So the majority of research studies of “DHEA” administered via <span style="text-decoration: underline;">oral</span> DHEA supplements and consequently showed little benefit to "DHEA"(Sulfate) were not testing DHEA with the proper method of administration.

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