Is DHEA Safe?
As a physician, I believe Twist 25 DHEA cream is the highest quality anti-aging and wellness product available.
Recent medical research studies show DHEA must be delivered to the body as a transdermal cream rather than as a pill supplement. There are 3 key reasons for this.
Reason 1) When taken as a pill, orally ingested DHEA is destroyed by the “first-pass effect” of the liver. Basically, this means that because the molecule is too large it appears to be a foreign substance, the liver filters most of the effective DHEA out before it can do any good: and, what does end up getting into the bloodstream is DHEA-S (DHEA sulphate).
Reason 2) DHEA-S is not the same as DHEA. DHEA-S is a different pro-hormone and has different benefits than DHEA. New medical research shows DHEA-S is not converted by the body into DHEA. However, DHEA is converted into DHEA-S, but not the other way around.
Twist 25 cream does supplement DHEA instead rather than DHEA-S.
(Fabian Hammer, Sandra Subtil, Philipp Lux, Christiane Maser-Gluth, Paul M. Stewart, Bruno Allolio and Wiebke Arlt. No Evidence for Hepatic Conversion of Dehydroepiandrosterone (DHEA) Sulfate to DHEA: In Vivo and in Vitro Studies. Journal of Clinical Endochrinology and Metabolism Vol. 90, No. 6 3600-3605)
So the majority of research studies of “DHEA” administered via oral DHEA supplements and consequently showed little benefit to “DHEA”(Sulfate) were not testing DHEA with the proper method of administration.